Key Takeaways:

  • Discover the top GABA supplements on the market, including Pure Encapsulations, Double Wood, NOW, Nutra Harmony, and Thorne PharmaGABA-100.
  • Understand how GABA supplementation can promote relaxation, improve sleep quality, and support a healthy response to stress.
  • Learn about the unique features of each supplement and how they can contribute to your overall mental and physical well-being.

GABA, or gamma-aminobutyric acid, is the primary inhibitory neurotransmitter in the central nervous system, playing a crucial role in regulating brain activity and promoting relaxation. With the increasing interest in natural ways to manage stress and improve sleep quality, GABA supplements have surged in popularity. In this review, we will delve into the best GABA supplements available, including Pure Encapsulations GABA, Double Wood GABA, NOW GABA, Nutra Harmony GABA, and Thorne PharmaGABA-100, to help you make an informed decision on which product might be the best fit for your health needs.

How We Choose

Our team has spent hours researching through thousands of user reviews and star ratings for the best GABA supplements on the market. We take into account factors such as taste, nutrition, ingredients, sustainability, and affordability when recommending products to our readers. We strive to find the best options that meet everyone’s needs - even those on a budget!

We hope you find your next special item from the list below! Each product was independently selected by our editors. Good Guru Reviews may collect a share of sales or other compensation from the links on this page if you decide to buy something (at no additional cost to you, that's how we stay in business). Enjoy finding your next special item!

In this article, we will look at five of the best GABA supplements on the market today and explain why they are worth investing in. Below, is the list of the best GABA supplementations we found.

Pure Encapsulations GABA Supplement: A Pure Choice for Relaxation

When it comes to purity and quality, Pure Encapsulations GABA supplement stands out. Free from major allergens, artificial additives, and gluten, this supplement is designed for those who are sensitive to certain ingredients. The inclusion of vitamin C in the form of ascorbyl palmitate may aid in GABA absorption, making it a potent choice for those seeking to promote relaxation and restful sleep.

The commitment of Pure Encapsulations to hypoallergenic formulations means that you can trust this supplement to be free from unwanted reactions. With a focus on promoting a healthy response to mental and physical tension, Pure Encapsulations GABA is a top contender for those prioritizing purity in their supplements.

Double Wood GABA Supplement: Double the Support for Stress Relief

Double Wood Supplements has created a GABA product that is both effective and accessible. Their GABA supplement is known for its ability to support relaxation and ease nervous tension. With a straightforward formula that avoids unnecessary fillers, Double Wood's GABA supplement is a strong option for those looking to manage stress and support immune health.

The company's dedication to third-party testing ensures that each batch meets high standards for quality and efficacy. For individuals seeking a reliable and potent GABA supplement, Double Wood's offering may provide the stress relief and mental health support they need.

NOW GABA Supplement: A Trusted Name in Stress Management

NOW Foods is a well-known brand in the supplement industry, and its GABA supplement is no exception when it comes to quality. Designed to support relaxation and a healthy stress response, the NOW GABA supplement includes vitamin B-6 to enhance GABA synthesis. This combination may help to improve sleep quality and reduce anxiety.

The affordability and wide availability of NOW GABA supplement make it an attractive option for those new to GABA supplementation. With a reputation for consistency and purity, NOW Foods provides a GABA supplement that many trust for daily stress management.

Nutra Harmony GABA Supplement: Harmonizing Your Health

Nutra Harmony offers a GABA supplement that aims to balance your health regimen. Their formula is designed to support relaxation and mental well-being, with an emphasis on natural ingredients. The inclusion of L-theanine, an amino acid found in green tea, works synergistically with GABA to enhance its calming effects.

Nutra Harmony's commitment to a gluten-free and non-GMO formula means that their GABA supplement is suitable for a wide range of dietary needs. For those seeking a harmonious approach to stress relief and sleep support, Nutra Harmony's GABA supplement could be the perfect addition to their health routine.

Thorne PharmaGABA-100 Supplement: The Natural Edge

Thorne's PharmaGABA-100 takes a unique approach by using a naturally sourced form of GABA. This fermented product is thought to mimic the GABA naturally produced in the human brain more closely, potentially offering better absorption and effectiveness. Thorne's commitment to clean, research-based formulations is evident in this high-quality supplement.

PharmaGABA-100 is designed to help individuals fall asleep faster and enjoy a good night's sleep, all while supporting a healthy stress response. For those who prefer supplements that are as close to nature as possible, Thorne's PharmaGABA-100 may be the ideal choice.

The Science Behind GABA Supplementation

GABA supplementation has been studied for its potential to support relaxation, reduce anxiety, and improve sleep issues. As the primary inhibitory neurotransmitter, GABA works by slowing down nerve signals in the brain, which can help to manage stress and promote a sense of calm. However, it's important to note that most supplements cannot cross the blood-brain barrier, which is why the form of GABA used in a supplement is crucial.

How Do GABA Supplements Work?

The effectiveness of GABA supplements is often debated due to the challenge of crossing the blood-brain barrier. However, some studies suggest that GABA supplementation can influence the body's peripheral nervous system and may have a calming effect on the brain indirectly. The presence of additional ingredients like L-theanine can also enhance the efficacy of GABA supplements by promoting GABA-like activity.

Choosing the Right GABA Supplement for You

When selecting a GABA supplement, consider factors such as ingredient purity, the presence of synergistic compounds, and your specific health condition. It's also important to look for products that are free from artificial additives and major allergens if you have sensitivities. Consulting with a healthcare professional before starting any new supplement regimen is always recommended.

GABA Supplementation and Diet: The Synergy for Well-being

When discussing the best GABA supplement, it's crucial to consider the synergy between supplementation and diet. GABA, or gamma-aminobutyric acid, is not only found in supplements but also naturally in fermented foods. Incorporating items like kefir, yogurt, and kimchi into your diet can enhance the effects of GABA supplements. This combination can lead to a more pronounced improvement in achieving a good night's sleep and managing stress levels. It's a holistic approach that maximizes the benefits of GABA's calming properties.

Moreover, for those with dietary restrictions, it's important to note that many high-quality GABA supplements are gluten-free and do not contain common allergens like rice flour or stearic acid. This makes them a safe addition to virtually any diet. By choosing a supplement that complements your dietary preferences, such as Thorne's GABA supplement, which is known for its purity and efficacy, you can ensure that you're supporting your mental health without compromising your dietary needs.

GABA Gamma Aminobutyric Acid: Beyond the Basics

GABA gamma-aminobutyric acid is not just another supplement; it's a naturally occurring neurotransmitter that plays a pivotal role in calming the nervous system. While many are familiar with its relaxing properties, few delve into the science of how GABA interacts with the brain's chemistry. It's fascinating to note that GABA's efficacy hinges on its ability to cross the blood-brain barrier, a selective permeability shield that protects the brain from potential toxins. This crossing is crucial for GABA to exert its tranquilizing effects, which can lead to a good night's sleep and a more balanced mental state.

Thorne's GABA supplement is often highlighted for its purity and effectiveness. As a frontrunner in the market, Thorne ensures that their product is gluten-free, catering to those with dietary restrictions while providing the benefits of synthetic GABA. This distinction is essential for consumers who are cautious about introducing supplements into their regimen, especially when considering interactions with prescription medication. Thorne's commitment to quality means that users can trust in the supplement's ability to contribute to their overall well-being without the worry of adverse effects.

Thorne's GABA Supplement: A Gluten-Free Gateway to Serenity

Thorne's GABA supplement stands out in the crowded market of stress-relief aids, not only for its efficacy but also for its commitment to purity. Gluten-free and designed to cater to those with dietary sensitivities, Thorne's formulation respects the delicate balance of the body's needs while providing the calming benefits of GABA. The absence of gluten ensures that individuals with celiac disease or gluten intolerance can embrace the tranquility offered by GABA without concern for adverse reactions.

Moreover, Thorne's GABA supplement is meticulously crafted to cross the blood-brain barrier effectively. This biological gateway protects the brain from potential toxins but can also limit the efficacy of certain supplements. Thorne's advanced formula is designed to navigate this hurdle, ensuring that the GABA reaches its target areas in the brain, thereby promoting a good night's sleep and an overall sense of calm.

Thorne's GABA Supplement: A Gluten-Free Solution for Cognitive Clarity

Thorne's GABA supplement stands out in the crowded market of stress-relief aids, not only for its commitment to purity but also for its gluten-free formulation. This is a significant advantage for individuals with gluten sensitivities or celiac disease, who often struggle to find supplements that align with their dietary restrictions. Thorne's meticulous attention to detail ensures that each capsule is free from gluten and other common allergens, making it a safe and inclusive option for a broad range of users.

Moreover, the inclusion of N-Acetyl L-Tyrosine in Thorne's GABA supplement enhances cognitive clarity. N-acetyl L-Tyrosine is an amino acid that supports brain function and has been shown to improve focus, especially in stressful situations. By combining GABA with N-Acetyl L-Tyrosine, Thorne's supplement offers a dual-action approach to mental wellness, promoting relaxation while sharpening the mind.

GABA and the Blood-Brain Barrier: Maximizing Absorption for a Good Night's Sleep

The effectiveness of GABA supplements is often questioned due to the blood-brain barrier, a selective permeability barrier that protects the brain from foreign substances. However, recent advancements in supplement formulation have led to the development of compounds that can cross this barrier more effectively. Thorne's GABA supplement, with its high-quality ingredients, is designed to maximize absorption and bioavailability, ensuring that the calming benefits of GABA can reach the brain and exert their effects.

A good night's sleep is crucial for overall health, and GABA plays a pivotal role in facilitating restful slumber. By calming neural activity, GABA supplements can help to quiet the mind and prepare the body for sleep. Users of Thorne's GABA supplement often report an improvement in sleep quality, attributing their more restful nights to the supplement's ability to cross the blood-brain barrier and promote relaxation at a neurological level. This makes Thorne's GABA supplement an excellent choice for those seeking natural support for sleep and relaxation.

L-Theanine and N-Acetyl L-Tyrosine: Complementary Companions to GABA

When it comes to enhancing the effects of GABA supplements, the inclusion of L-Theanine and N-Acetyl L-Tyrosine can be a game-changer. L-Theanine, an amino acid found in green tea, is known for its ability to promote relaxation without drowsiness. It complements GABA's effects by aiding in the achievement of a good night's sleep, making it an excellent addition for those seeking a restful slumber. The synergy between GABA and L-theanine can lead to improved sleep quality and a more peaceful state of mind.

N-acetyl L-Tyrosine, on the other hand, is a modified form of the amino acid tyrosine, known for its role in the production of dopamine and norepinephrine—neurotransmitters that influence mood and stress responses. By supporting the body's ability to adapt to stress, N-Acetyl L-Tyrosine works in concert with GABA supplements to provide a comprehensive approach to stress relief. This combination not only helps in managing stress but also supports cognitive function during times of pressure.

Synergistic Effects of GABA with L-Theanine and N-Acetyl L-Tyrosine

When discussing GABA supplementation, it's impossible to overlook the synergistic relationship it shares with other amino acids, such as L-Theanine and N-Acetyl L-Tyrosine. L-Theanine, commonly found in green tea, is known for its ability to promote relaxation without drowsiness. When paired with GABA, the combination can be particularly potent for those seeking stress relief and a good night's sleep. The two compounds work in harmony to enhance the overall calming effect, potentially leading to improved sleep quality and a more serene mental state.

N-acetyl L-Tyrosine, on the other hand, is a precursor to several neurotransmitters, including dopamine and norepinephrine. This amino acid can support cognitive function, especially in stressful situations. When combined with GABA supplements, the result is a balanced approach to stress management. However, it's important to be mindful of the dosage to avoid the risk of too much GABA, which can lead to adverse effects. A well-considered supplementation plan that includes these complementary amino acids can offer a holistic strategy to support the nervous system and mental health.

The Role of Complementary Amino Acids in GABA Supplementation

While GABA supplements are effective on their own, the inclusion of complementary amino acids can enhance their efficacy. For instance, N-acetyl L-tyrosine is an amino acid that supports the production of neurotransmitters, which can work in tandem with GABA to promote mental clarity and a calm state of mind. Additionally, L-theanine, commonly found in green tea, is another amino acid that pairs well with GABA supplements. It has been shown to cross the blood-brain barrier effectively, promoting relaxation without drowsiness.

The presence of silicon dioxide in some supplements can prevent clumping and ensure that the active ingredients are evenly distributed, which is particularly beneficial when the supplement is in lozenge form. By understanding the role of these complementary substances, consumers can make more informed decisions about their GABA supplementation regimen and optimize their mental health outcomes.

The Role of GABA in Sleep Quality

GABA's ability to promote relaxation and reduce mental and physical tension makes it a popular supplement for those struggling with sleep quality. By calming the nervous system, GABA supplements can help individuals fall asleep faster and achieve a more restful night's sleep. However, the effectiveness can vary from person to person, and higher doses may be required for noticeable benefits.

GABA and Stress Relief: A Natural Solution

In today's fast-paced world, finding natural solutions for stress relief is more important than ever. GABA supplements offer a potential way to support a healthy response to stress without the need for prescription medications. By naturally regulating brain activity, GABA can help to ease nervous tension and promote a sense of calm.

Potential Side Effects of Taking GABA Supplements

While GABA supplements are generally considered safe, some individuals may experience side effects such as an upset stomach or drowsiness, especially at higher doses. It's important to start with a lower daily dose and gradually increase it as needed, under the guidance of a healthcare professional. Always be mindful of how your body reacts to any new supplement.

GABA Supplementation and Mental Health

Mental health is a complex issue, and GABA supplementation may offer support for those dealing with anxiety and stress. By promoting a calming effect on the nervous system, GABA supplements can contribute to a healthier mental state. However, they should not be seen as a cure-all and are best used as part of a comprehensive approach to mental health care.

The Importance of Quality in GABA Supplements

The quality of GABA supplements can vary widely between brands. Look for companies that prioritize high-quality ingredients, third-party testing, and transparency in their formulations. Supplements that contain pure GABA or naturally sourced GABA, like Thorne's PharmaGABA-100, may offer better results due to their potential for improved absorption and effectiveness.

GABA Supplements and Other Health Benefits

Beyond stress relief and sleep support, GABA supplements may offer additional health benefits. Some research suggests that GABA can help lower blood pressure, support muscle mass, and even contribute to a healthy immune system. While more research is needed, the potential health benefits of GABA supplementation make it a promising addition to a wellness routine.

Combining GABA with Other Supplements

GABA supplements can be taken on their own or in combination with other supplements for enhanced effects. For example, pairing GABA with L-theanine, found in green tea, may provide a synergistic effect that supports relaxation and stress management. Always consult with a healthcare professional before combining supplements to ensure safety and efficacy.

Understanding GABA Levels and Supplementation

Naturally produced GABA is essential for maintaining a balanced nervous system. However, not everyone produces enough GABA, which can lead to feelings of anxiety and difficulty falling asleep. GABA supplementation can help to replenish low levels, but it's important to understand that more is not always better. Finding the right balance is key to effective supplementation.

The Future of GABA Supplementation

As research continues to evolve, the future of GABA supplementation looks promising. With a growing understanding of how GABA and its supplements work within the body, we can expect to see more targeted and effective products entering the market. The potential for GABA to support a wide range of health concerns makes it an exciting area of study.


GABA supplements have become a popular choice for those seeking natural ways to promote relaxation, improve sleep quality, and manage stress. In this comprehensive review, we've explored the best GABA supplements, including Pure Encapsulations GABA, Double Wood GABA, NOW GABA, Nutra Harmony GABA, and Thorne PharmaGABA-100. Each product offers unique features that cater to different needs, from purity and allergen-free formulations to naturally sourced GABA and synergistic ingredients. Whether you're looking to reduce anxiety, support mental health, or simply enjoy a better night's sleep, GABA supplements may provide the natural support you need.

If you're ready to give your body the love it deserves, check out one of these special items above. We are sure you won't be disappointed!

As always, consult with your physician before starting any new supplement regimen to check about potential interactions with other supplements or medications. The information presented in this document is purely for educational purposes and should not be construed as medical advice.

While every effort has been made to ensure the accuracy and reliability of the information provided, all health-related decisions should be made in consultation with a qualified healthcare professional. The author does not take any liability for the health decisions made by the reader.

Dietary supplements are not regulated the way drugs are in the United States. This means the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. When possible, choose a supplement tested by a trusted third party, such as Consumer Labs, USP, or NSF.

FAQ Section

Q: Can GABA supplements help with anxiety? A: Yes, GABA supplements may help to reduce anxiety by promoting relaxation and regulating brain activity. However, individual results can vary, and they should be used as part of a comprehensive approach to anxiety management.

Q: Are there any side effects to taking GABA supplements? A: Some individuals may experience side effects such as an upset stomach or drowsiness, particularly at higher doses. It's important to start with a lower dose and consult with a healthcare professional.

Q: Can I take GABA supplements with other medications or supplements? A: It's essential to consult with a healthcare professional before combining GABA supplements with other medications or supplements to avoid potential interactions and ensure safety.